Scientist Protein Biochemistry | TUM | Faculty of Chemistry Garching | Germany

Website TUM - Technical University Munich

Scientist Protein Biochemistry | TUM | Faculty of Chemistry Garching | Germany

JOB DESCRIPTION

We aim at developing next-generation precision medicines for unmet medical needs. Our focus is on the engineering of innovative immunomodulatory biologics. Within this endeavor, we have created alphaSEPT. AlphaSEPT is a novel signaling molecule within the human immune system. It is a potential first-in-class pharmaceutical to treat sepsis, an infectious disease with very high mortality rates and no causative treatment options available. Currently, we are looking for a highly motivated protein biochemist to strengthen our newly established team.

The ideal candidate will drive the early pre-clinical development of alphaSEPT. He/She will work on the production, biophysical characterization, and development of alphaSEPT towards a biopharmaceutical ready for the clinics. The candidate will work in the in-house lab as well as with several academic cooperation partners at other institutions and contract research organizations (CROs).

RESPONSIBILITIES

  • Development of a lead candidate via protein engineering;
  • Protein expression from mammalian and bacterial cell cultures;
  • Protein purification via advanced techniques;
  • Biophysical characterization of proteins;
  • Drug substance formulation development;
  • Development lead of a master cell bank;
  • Data analysis and presentations;
  • Establishing standard operating procedures (SOPs);
  • The lead of a small team.

QUALIFICATIONS

  • Ph.D. in protein biochemistry or similar fields;
  • Substantial expertise in mammalian cell culture;
  • Substantial expertise in protein engineering, protein expression, protein purification, and biophysical characterization;
  • Experience in (pre-)clinical development of biopharmaceuticals (e.g. formulation development) and molecular immunology is a plus;
  • Know-how in GLP and GMP requirements is a plus.

THE ENVIRONMENT AND THE POSITION

The position is associated with the laboratory of Cellular Protein Biochemistry (www.cell.ch.tum.de) at the Technical University of Munich (TUM), a leading research university in Europe. The salary is in accordance with the Public Sector Collective Agreement on Länder (TV-L E13/100%). The position is limited to two years. The earliest starting date is October 1st, 2020.

We are looking forward to your application including a CV, (degree) certificates, a letter of motivation, and at least two possible references. Please send your application as a single pdf document by email to- [email protected].

TUM is an equal opportunity employer. Qualified women are therefore particularly encouraged to apply. Applicants with disabilities are treated with preference given comparable qualifications.

Scientist Protein Biochemistry | TUM | Faculty of Chemistry Garching | Germany

To apply for this job email your details to matthias.feige@tum.de