PhD in Bioinformatics – German Cancer Research Center, Location – Heidelberg, Application Deadline: 28.04.2020, Earliest Possible Start Date: 01.08.2020
PhD position in Bioinformatics
- Department: Pediatric Neurooncology
- Code number: 2020-0107
About the Company
Germany’s largest biomedical research institution is the German Cancer Research Centre. A large scientific program in the field of cancer research is running with approximately 3,000 employees.
The Clinical Bioinformatics Group (https:/www.kitz-heidelberg.de/e/en/research/research/cns-brain-tumors/clinical-group-bioinformatics/) is in an extremely dynamic research environment in DKFZ and KiTZ and is looking to join the full-time PhD team. The team aims at motivating bioinformatician participation.
The successful candidate is part of the interdisciplinary research team developing and applying a range of cutting-edge methodologies to improve childhood cancer diagnosis, treatment and early detection. He / she will use bioinformatics and statistical methods for the analysis and interpretation of high-performance omics data.
About the project
The project “Sets for defining new vulnerability networks for pediatric brain cancer to analyze and integrate high-throughput functional genomics data” focusses on central nervous tumor systems which are the common solid infant tumor. Although low-grade gliomas (LGGs) are more common than high-grade malignant gliomas (HGGs), HGGs contribute significantly to deaths from cancer in both kids and adults. Histone H3 mutations, a genomic feature rarely seen in adult HGGs, are the typical genomic lesions of pediatric HGGs. Interestingly, Histone H3 mutations are not scattered randomly across genomic loci H3, but they almost always affect K27 and G34 residues.
The survival rates of HGG children remained low despite highly intense treatment regimens and powerful molecular characterisation studies. It is hoped that cancer-exclusive processes will ultimately improve HGG therapy significantly. To systemically identify the genomic lesions found in pediatric genomics we have started working in collaboration with Dr Christian Braun (https:/www.ccrc-hauner.de/braun-lab/48534a730dc8e62f) on functional genomic screens based upon CRISPR I / a / c, RNAi and single-cell barcoding.
A computational integration of screening and omics data sets over a broad range of glioma subtypes is now key to the systemic creation of this functional information layer.
The PhD project’s objectives are
- The development and
- The implementation of statistical frameworks for the analysis of collective high-performance genomics screens,
- Integration of those data sets with existing data for characterizing deep multi-omics, and
- Identification of large, or subtype-specific, networks for vulnerability to children’s cancer. Therefore the successful candidate addresses new investigative issues at the intersection of pediatric cancer research and computational biology.
- Master’s degree in bioinformatics or a related scientific discipline (e.g. computational biology, statistics, computer science, or molecular biotechnology)
- Strong analytical skills, as well as broad experience with multiple scripting languages (Python, R, Bash, for example), common bioinformatics software and databases are essential
- Experience in working in high-performance computing environments is beneficial
- Reliability, attention to detail, communication skills and the ability to work in a multidisciplinary international team will be expected
Interested and qualified applicants should at least submit a cover letter with references and a curriculum vitae.
- Interesting, versatile workplace
- International, attractive working environment
- Campus with modern state-of-the-art infrastructure
- Access to international research networks
- Doctoral student payment including social benefits
- Flexible working hours
- Comprehensive training and mentoring program through the Helmholtz International Graduate School
Earliest Possible Start Date: 01.08.2020
Duration: The position is limited to 3 years with the possibility of prolongation.
Application Deadline: 28.04.2020
Dr Natalie Jäger
Please note that we do not accept applications submitted via email.
To Apply click HERE.
The German Cancer Research Center is committed to increasing the proportion of women scientists and encourages women to apply. A person with disabilities will be given preference amongst candidates with equal skills and qualifications.
Please use the online application portal (www.dkfz.de/jobs) for a position application.
We ask for your understanding that we cannot return postal documents (Deutsches Krebsforschungszentrum, Personalabteilung, Im Neuenheimer Feld 280 69120 Heidelberg). We do not agree to email applications. We excuse you for any discomfort that may result.
PhD in Bioinformatics – German Cancer Research Center
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